Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 8/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.37 |
| ▸ | RAF1 | P04049 | 2/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.37 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.37 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24669827 | 0.86 | CRBN (0.60) | CRBNDDB1PTK2RAF1CCNC | |
| SCHEMBL22951135 | 0.85 | CRBN (0.48) | CRBNDDB1ESR1RAF1CCNC | |
| SCHEMBL24299447 | 0.84 | CRBN (0.55) | CRBNDDB1 | |
| SCHEMBL24734974 | 0.84 | CRBN (0.51) | CRBNDDB1ESR1 | |
| SCHEMBL24735226 | 0.84 | CRBN (0.59) | CRBNDDB1PTK2RAF1CCNC | |
| SCHEMBL29223778 | 0.84 | CRBN (0.43) | CRBNDDB1ESR1EGFRAR | |
| SCHEMBL29841470 | 0.84 | CRBN (0.59) | CRBNDDB1PTK2RAF1CCNC | |
| SCHEMBL24735577 | 0.83 | CRBN (0.58) | CRBNDDB1PTK2RAF1CCNC | |
| SCHEMBL21982914 | 0.83 | CRBN (0.48) | CRBNDDB1ESR1AR | |
| SCHEMBL23705525 | 0.83 | CRBN (0.62) | CRBNDDB1RAF1CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081450-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |