Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21961740 | 0.94 | TYK2 (0.46) | TYK2KDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL21947279 | 0.93 | TYK2 (0.51) | TYK2KDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL21960683 | 0.93 | TYK2 (0.54) | TYK2KDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL20689035 | 0.92 | TYK2 (0.49) | TYK2KDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL21227479 | 0.89 | TYK2 (0.52) | TYK2 | |
| SCHEMBL20688015 | 0.88 | TYK2 (0.54) | TYK2 | |
| SCHEMBL20688012 | 0.88 | TYK2 (0.54) | TYK2 | |
| SCHEMBL20697201 | 0.88 | TYK2 (0.43) | TYK2 | |
| SCHEMBL20687999 | 0.88 | TYK2 (0.54) | TYK2 | |
| SCHEMBL21963459 | 0.87 | TYK2 (0.51) | TYK2KDM4ENPC1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081508-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2020-04-23 | — | — | WO | disclosed |