Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 16/20 | 0.55 |
| ▸ | JAK3 | P52333 | 12/20 | 0.55 |
| ▸ | LCK | P06239 | 11/20 | 0.55 |
| ▸ | EGFR | P00533 | 7/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18884592 | 0.89 | BTK (0.64) | BTKJAK3LCKEGFR | |
| SCHEMBL23081118 | 0.83 | LCK (0.54) | BTKJAK3LCKEGFR | |
| SCHEMBL18884637 | 0.83 | BTK (0.64) | BTKJAK3LCKEGFR | |
| SCHEMBL20867876 | 0.82 | BTK (0.64) | BTKJAK3LCKEGFR | |
| SCHEMBL25649437 | 0.82 | JAK3 (0.57) | BTKJAK3LCKEGFR | |
| SCHEMBL25593539 | 0.81 | BTK (0.49) | BTKJAK3LCKEGFR | |
| SCHEMBL16801813 | 0.81 | JAK3 (0.70) | BTKJAK3LCKEGFR | |
| SCHEMBL21855218 | 0.81 | JAK3 (0.86) | BTKJAK3LCKEGFR | |
| SCHEMBL21947754 | 0.81 | JAK3 (0.86) | BTKJAK3LCKEGFR | |
| SCHEMBL28642920 | 0.81 | JAK3 (0.86) | BTKJAK3LCKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081450-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |