Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 3/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20687945 | 0.94 | KDM4E (0.44) | KDM4EHPGDHSD17B10ALDH1A1NPC1 | |
| SCHEMBL21238637 | 0.87 | KDM4E (0.42) | KDM4EHPGDHSD17B10ALDH1A1NPC1 | |
| SCHEMBL20697361 | 0.84 | KDM4E (0.42) | KDM4EHPGDHSD17B10ALDH1A1NPC1 | |
| SCHEMBL20689335 | 0.84 | KDM4E (0.43) | KDM4EHPGDHSD17B10ALDH1A1NPC1 | |
| SCHEMBL21961793 | 0.82 | KDM4E (0.42) | KDM4EHPGDHSD17B10ALDH1A1NPC1 | |
| SCHEMBL21947290 | 0.82 | KDM4E (0.48) | KDM4EHPGDHSD17B10ALDH1A1NPC1 | |
| SCHEMBL21947268 | 0.81 | TYK2 (0.43) | TYK2 | |
| SCHEMBL21246236 | 0.81 | TYK2 (0.41) | KDM4EHPGDHSD17B10ALDH1A1NPC1 | |
| SCHEMBL21948058 | 0.81 | KDM4E (0.47) | KDM4EHPGDHSD17B10ALDH1A1NPC1 | |
| SCHEMBL20696964 | 0.80 | TYK2 (0.53) | KDM4EHPGDHSD17B10ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081508-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2020-04-23 | — | — | WO | disclosed |