Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 11/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14372529 | 0.81 | BRD4 (0.63) | BRD4P2RX7MAPTSMN1; SMN2POLB | |
| SCHEMBL13803892 | 0.81 | BRD4 (0.63) | BRD4P2RX7MAPTSMN1; SMN2POLB | |
| SCHEMBL24017871 | 0.77 | MEN1 (0.32) | BRD4MEN1ALDH1A1KMT2A | |
| SCHEMBL15684270 | 0.77 | BRD4 (0.63) | BRD4KMT2AMAPTSMN1; SMN2POLB | |
| SCHEMBL119901 | 0.77 | BRD4 (0.63) | BRD4KMT2AMAPTSMN1; SMN2POLB | |
| SCHEMBL2811918 | 0.77 | BRD4 (0.63) | BRD4KMT2AMAPTSMN1; SMN2POLB | |
| SCHEMBL30307671 | 0.77 | BRD4 (0.63) | BRD4KMT2AMAPTSMN1; SMN2POLB | |
| SCHEMBL5190581 | 0.75 | BRD4 (0.61) | BRD4MEN1ALDH1A1KMT2AP2RX7 | |
| SCHEMBL15042119 | 0.74 | BRD4 (0.51) | BRD4ALDH1A1P2RX7MAPTSMN1; SMN2 | |
| SCHEMBL10926154 | 0.73 | BRD4 (0.59) | BRD4P2RX7MAPTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081508-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2020-04-23 | — | — | WO | disclosed |