⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29646187 | 1.00 | — | — | |
| SCHEMBL10955792 | 0.80 | — | — | |
| SCHEMBL27995063 | 0.80 | — | — | |
| SCHEMBL15423564 | 0.80 | — | — | |
| SCHEMBL27811554 | 0.78 | — | — | |
| SCHEMBL5796971 | 0.78 | — | — | |
| SCHEMBL11167057 | 0.78 | — | — | |
| SCHEMBL11941447 | 0.78 | — | — | |
| SCHEMBL2967944 | 0.75 | HTT (0.41) | — | |
| SCHEMBL10329693 | 0.75 | HTT (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12358896-B2 | LRRK2 inhibitors and methods of making and using thereof | DENALI THERAPEUTICS INC. (US) | 2025-07-15 | — | — | US | disclosed |
| EP-3953348-B1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC (US) | 2024-12-18 | — | — | EP | disclosed |
| US-20220220094-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | DENALI THERAPEUTICS INC. (US) | 2022-07-14 | — | — | US | disclosed |
| US-20220153728-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2022-05-19 | — | — | US | disclosed |
| EP-3953348-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | Denali Therapeutics Inc. (US) | 2022-02-16 | — | — | EP | disclosed |
| CN-113939294-A | Compounds, compositions and methods | 戴纳立制药公司 | 2022-01-14 | — | — | CN | disclosed |
| WO-2020210684-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2020-10-15 | — | — | WO | disclosed |
| US-20200157081-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. | 2020-05-21 | — | — | US | disclosed |