Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 16/20 | 0.66 |
| ▸ | SCN8A | Q9UQD0 | 16/20 | 0.66 |
| ▸ | SCN5A | Q14524 | 14/20 | 0.66 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21783524 | 0.80 | SCN1A (1.00) | SCN1ASCN8ASCN5A | |
| Formic Acid SCHEMBL21955463 | 0.78 | SCN1A (0.92) | SCN1ASCN8ASCN5A | |
| Formic Acid SCHEMBL30047265 | 0.78 | SCN1A (0.92) | SCN1ASCN8ASCN5A | |
| SCHEMBL21955481 | 0.76 | SCN8A (0.70) | SCN1ASCN8ASCN5A | |
| SCHEMBL21955483 | 0.74 | SCN1A (0.71) | SCN1ASCN8ASCN5A | |
| SCHEMBL21783526 | 0.71 | SCN1A (0.67) | SCN1ASCN8ASCN5AMAPK8MAPK9 | |
| SCHEMBL21773121 | 0.70 | NPC1 (0.32) | SCN1ASCN8ASCN5A | |
| SCHEMBL21777202 | 0.70 | SCN8A (0.35) | SCN1ASCN8ASCN5A | |
| SCHEMBL21778000 | 0.69 | SCN1A (0.64) | SCN1ASCN8ASCN5A | |
| SCHEMBL21778001 | 0.69 | SCN1A (0.64) | SCN1ASCN8ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11639351-B2 | Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC. | 2023-05-02 | — | — | US | disclosed |
| US-10981905-B2 | Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2021-04-20 | — | — | US | disclosed |
| US-20200157089-A1 | HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11639351-B2 | Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents | SCN1A, SCN2A, SCN2B | SCN1A 1/4885SCN8A 6/4885SCN5A 7/4885 |
| US-20200157089-A1 | HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | SCN1A, SCN2A, SCN2B | SCN1A 1/4885SCN8A 6/4885SCN5A 7/4885 |
| US-10981905-B2 | Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents | SCN1A, SCN2A, SCN2B | SCN1A 1/4885SCN8A 6/4885SCN5A 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.