Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 11/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KRAS | P01116 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21958155 | 1.00 | TEAD1 (0.60) | TEAD1KDM4ETDP1ALDH1A1KRAS | |
| SCHEMBL25785411 | 0.89 | TEAD1 (0.48) | TEAD1KRASJAK3 | |
| SCHEMBL21958248 | 0.87 | TEAD1 (0.60) | TEAD1KRASJAK3 | |
| SCHEMBL21958962 | 0.84 | TEAD1 (0.57) | TEAD1KRAS | |
| SCHEMBL21958174 | 0.84 | TEAD1 (0.57) | TEAD1KRAS | |
| SCHEMBL24780719 | 0.80 | TEAD1 (0.71) | TEAD1 | |
| SCHEMBL21957254 | 0.80 | TEAD1 (0.71) | TEAD1 | |
| SCHEMBL21958163 | 0.80 | TEAD1 (0.71) | TEAD1 | |
| SCHEMBL21958157 | 0.79 | TEAD1 (0.60) | TEAD1KRASJAK3 | |
| SCHEMBL21958183 | 0.79 | TEAD1 (0.60) | TEAD1KRASJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081572-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |