Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NCF1 | P14598 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.31 |
| ▸ | CHKA | P35790 | 1/20 | 0.31 |
| ▸ | PHGDH | O43175 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18807723 | 1.00 | HRH3 (0.37) | HRH3LMNAMGLLTDP1KDM4E | |
| SCHEMBL11138954 | 1.00 | HRH3 (0.37) | HRH3LMNAMGLLTDP1KDM4E | |
| SCHEMBL12316976 | 1.00 | HRH3 (0.37) | HRH3LMNAMGLLTDP1KDM4E | |
| SCHEMBL20124473 | 1.00 | HRH3 (0.37) | HRH3LMNAMGLLTDP1KDM4E | |
| SCHEMBL414741 | 1.00 | HRH3 (0.37) | HRH3LMNAMGLLTDP1KDM4E | |
| N-Methylpiperidine SCHEMBL1920 | 1.00 | — | — | |
| N-Methylpiperidine SCHEMBL6660565 | 1.00 | HRH3 (0.37) | HRH3LMNAMGLLTDP1KDM4E | |
| SCHEMBL3793955 | 1.00 | HRH3 (0.37) | HRH3LMNAMGLLTDP1KDM4E | |
| SCHEMBL12952612 | 1.00 | HRH3 (0.37) | HRH3LMNAMGLLTDP1KDM4E | |
| N-Methylpiperidine SCHEMBL11736662 | 1.00 | HRH3 (0.37) | HRH3LMNAMGLLTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |