Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADM2 | Q7Z4H4 | 19/20 | 0.64 |
| ▸ | CALCB | P10092 | 18/20 | 0.64 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22014049 | 0.90 | ADM2 (0.64) | ADM2CALCB | |
| SCHEMBL29813986 | 0.90 | ADM2 (0.64) | ADM2CALCB | |
| SCHEMBL29813944 | 0.90 | ADM2 (0.64) | ADM2CALCB | |
| SCHEMBL23257881 | 0.90 | ADM2 (0.60) | ADM2CALCBCALCRL | |
| SCHEMBL22015186 | 0.90 | ADM2 (0.64) | ADM2CALCB | |
| SCHEMBL27314297 | 0.90 | ADM2 (0.59) | ADM2CALCBCALCRL | |
| SCHEMBL22014289 | 0.89 | ADM2 (0.71) | ADM2CALCBCALCRL | |
| SCHEMBL23257397 | 0.85 | ADM2 (0.71) | ADM2CALCBCALCRL | |
| SCHEMBL20564417 | 0.84 | ADM2 (0.74) | ADM2CALCB | |
| SCHEMBL20564740 | 0.84 | ADM2 (0.74) | ADM2CALCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880308-A1 | HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS | The University Of Sheffield (GB) | 2021-09-22 | — | — | EP | disclosed |
| WO-2020099885-A1 | HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS | THE UNIVERSITY OF SHEFFIELD (GB) | 2020-05-22 | — | — | WO | disclosed |