SCHEMBL219654

SCHEMBL219654

O=C(O)c1ccc(OC(F)(F)F)cc1

nearest known ligand 0.68

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 5/20 0.68
FAAH O00519 3/20 0.68
TSHR P16473 2/20 0.62
ALDH1A1 P00352 1/20 0.62
HSD17B10 Q99714 1/20 0.62
AURKA O14965 1/20 0.60
TPX2 Q9ULW0 1/20 0.60
MRGPRX4 Q96LA9 1/20 0.55
CA1 P00915 1/20 0.54
CA2 P00918 1/20 0.54
TRPV1 Q8NER1 3/20 0.53
TP53 P04637 1/20 0.52
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50
PDE5A O76074 1/20 0.50
RXRA P19793 1/20 0.50
RXRB P28702 1/20 0.50
RXRG P48443 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8086285 0.98 EPHX2 (0.66) EPHX2FAAHTSHRALDH1A1HSD17B10
SCHEMBL6108041 0.94 EPHX2 (0.77) EPHX2FAAHTSHRALDH1A1HSD17B10
SCHEMBL22721360 0.94 EPHX2 (0.62) EPHX2FAAHTSHRALDH1A1HSD17B10
SCHEMBL505538 0.94 AURKA (0.69) EPHX2FAAHTSHRALDH1A1HSD17B10
SCHEMBL5473190 0.89 EPHX2 (0.70) EPHX2FAAHTSHRALDH1A1HSD17B10
SCHEMBL6110185 0.86 EPHX2 (0.91) EPHX2FAAHTRPV1NPC1RAB9A
SCHEMBL27635652 0.86 PLA2G4B (0.64) EPHX2FAAHTSHRALDH1A1HSD17B10
SCHEMBL22721344 0.85 MRGPRX4 (0.70) MRGPRX4NPC1RAB9ARXRARXRB
SCHEMBL4475347 0.84 NPC1 (0.60) EPHX2FAAHAURKATPX2TRPV1
SCHEMBL20015846 0.84 EPHX2 (0.57) EPHX2FAAHAURKATPX2TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1125 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4661890-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS Purdue Research Foundation (US) 2025-12-17 EP claimed
WO-2025202864-A1 ENT1 INHIBITORS IN COMBINATION WITH ONCOLYTIC VIRUSES AND THEIR USE IN THE TREATMENT OF CANCER iTeos Belgium SA (BE) 2025-10-02 WO claimed
WO-2025126110-A1 ENT1 INHIBITORS IN COMBINATION WITH BISPECIFIC ANTIBODIES iTeos Belgium SA (BE) 2025-06-19 WO claimed
WO-2025104613-A1 ENT1 INHIBITORS IN COMBINATION WITH CHECKPOINT INHIBITORS iTeos Belgium SA (BE) 2025-05-22 WO claimed
CN-118909783-B Preparation method of mycelium leather 无锡君臻生物科技有限公司 2025-05-09 CN claimed
CN-119841727-A Method for directly preparing carboxylic ester compound from aromatic aldehyde, ketone and carboxylic acid 湖南第一师范学院 2025-04-18 CN claimed
CN-118909783-A Preparation method of mycelium leather 无锡君臻生物科技有限公司 2024-11-08 CN claimed
WO-2024167565-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS PURDUE RESEARCH FOUNDATION (US) 2024-08-15 WO claimed
CN-118184679-A Photothermal agent and preparation method thereof, photothermal nanoparticle and preparation method thereof, insulating material and self-repairing method of insulating material 中国石油天然气股份有限公司 2024-06-14 CN claimed
CN-117567441-A Forskolin diterpenoid ester derivative and preparation method and application thereof 南通大学附属医院 2024-02-20 CN claimed
EP-0962464-A2 Methods and compositions for detecting binding of ligand pair using non-fluorescent label Rapigene, Inc. (US) 1999-12-08 EP claimed
WO-1999005319-A9 METHODS AND COMPOUNDS FOR ANALYZING NUCLEIC ACIDS BY MASS SPECTROMETRY RAPIGENE INC (US) 1999-06-17 WO claimed
CN-1212021-A Method and compositions for determining sequence of nucleic acid molecules RAPIGENE INC (US) 1999-03-24 CN claimed
WO-1999005319-A2 METHODS AND COMPOUNDS FOR ANALYZING NUCLEIC ACIDS BY MASS SPECTROMETRY RAPIGENE, INC. (US) 1999-02-04 WO claimed
EP-0868535-A2 METHODS AND COMPOSITIONS FOR DETERMINING THE SEQUENCE OF NUCLEIC ACID MOLECULES Rapigene, Inc. (US) 1998-10-07 EP claimed
EP-0850320-A2 METHODS AND COMPOSITIONS FOR DETECTING BINDING OF LIGAND PAIR USING NON-FLUORESCENT LABEL DARWIN MOLECULAR CORPORATION (US) 1998-07-01 EP claimed
WO-1997027331-A9 METHODS AND COMPOSITIONS FOR DETERMINING THE SEQUENCE OF NUCLEIC ACID MOLECULES 1997-10-09 WO claimed
WO-1997027331-A2 METHODS AND COMPOSITIONS FOR DETERMINING THE SEQUENCE OF NUCLEIC ACID MOLECULES RAPIGENE, INC. (US) 1997-07-31 WO claimed
WO-1997027327-A2 METHODS AND COMPOSITIONS FOR DETECTING BINDING OF LIGAND PAIR USING NON-FLUORESCENT LABEL RAPIGENE, INC. (US) 1997-07-31 WO claimed
US-5219477-A Containing organometallic salts and inorganic metal borates; fromo reactinmetal hydroxide with phenols or aromatic carboxylic acid THE DOW CHEMICAL COMPANY (US) 1993-06-15 US claimed