Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 13/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 13/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.49 |
| ▸ | PDE4A | P27815 | 4/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21969543 | 0.88 | PDE3B (0.49) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL21969526 | 0.86 | PDE3B (0.50) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL21969542 | 0.85 | PDE3B (0.49) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL21969530 | 0.85 | PDE3B (0.63) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL9686193 | 0.84 | PDE3B (0.44) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL7294591 | 0.84 | PDE3B (0.44) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL21969547 | 0.82 | PDE3B (0.46) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL11758847 | 0.81 | SMN1; SMN2 (0.42) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL11750645 | 0.81 | MAPT (0.48) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL11753250 | 0.81 | PDE3B (0.49) | PDE3BPDE3ASMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970145-B1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER | BROAD INST INC (US) | 2020-05-06 | — | — | EP | disclosed |