Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | GALR3 | O60755 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | PDE3B | Q13370 | 16/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 16/20 | 0.56 |
| ▸ | PDE4A | P27815 | 3/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10736918 | 0.88 | GALR3 (0.72) | SMN1; SMN2GALR3MAPTPDE3BPDE3A | |
| SCHEMBL21970121 | 0.87 | PDE3B (0.59) | SMN1; SMN2GALR3MAPTPDE3BPDE3A | |
| SCHEMBL10558594 | 0.83 | PDE3B (0.65) | SMN1; SMN2GALR3MAPTPDE3BPDE3A | |
| SCHEMBL21970685 | 0.83 | PDE3B (0.65) | SMN1; SMN2GALR3MAPTPDE3BPDE3A | |
| SCHEMBL16157214 | 0.83 | MAPT (1.00) | SMN1; SMN2GALR3MAPTPDE3BPDE3A | |
| SCHEMBL31117000 | 0.82 | PDE3B (0.61) | SMN1; SMN2GALR3MAPTPDE3BPDE3A | |
| SCHEMBL16157204 | 0.82 | PDE3B (0.61) | SMN1; SMN2GALR3MAPTPDE3BPDE3A | |
| SCHEMBL16157009 | 0.82 | PDE3B (0.76) | SMN1; SMN2GALR3MAPTPDE3BPDE3A | |
| SCHEMBL7276856 | 0.80 | GALR3 (0.59) | SMN1; SMN2GALR3MAPTPDE3BPDE3A | |
| SCHEMBL16157205 | 0.79 | PDE3B (0.66) | GALR3MAPTPDE3BPDE3APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970145-B1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER | BROAD INST INC (US) | 2020-05-06 | — | — | EP | disclosed |