Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.78 |
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | APEX1 | P27695 | 1/20 | 0.74 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.36 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | CPT1A | P50416 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betaine SCHEMBL19642750 | 0.88 | TSHR (0.88) | TSHRLMNAALDH1A1APEX1MAPT | |
| Betaine SCHEMBL399905 | 0.88 | TSHR (1.00) | TSHRLMNAALDH1A1APEX1MAPT | |
| Betaine SCHEMBL134333 | 0.88 | — | — | |
| Betaine SCHEMBL5965072 | 0.85 | TSHR (0.64) | TSHRLMNAALDH1A1APEX1CA1 | |
| Betaine SCHEMBL1318276 | 0.85 | — | — | |
| Betaine SCHEMBL1312998 | 0.85 | — | — | |
| Betaine SCHEMBL912129 | 0.85 | — | — | |
| Betaine SCHEMBL16046840 | 0.85 | — | — | |
| Betaine SCHEMBL9485249 | 0.85 | — | — | |
| Betaine SCHEMBL3234684 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111133557-B | Thermally removable filler material for anti-stiction applications | 霍尼韦尔国际公司 | 2023-11-24 | — | — | CN | disclosed |
| CN-106065278-B | Polysiloxane compositions and coatings for optoelectronic applications | 霍尼韦尔国际公司 | 2021-08-10 | — | — | CN | disclosed |
| US-10748757-B2 | Thermally removable fill materials for anti-stiction applications | HONEYWELL INTERNATIONAL, INC. (US) | 2020-08-18 | — | — | US | disclosed |
| CN-111133557-A | Thermally removable fill material for anti-stiction applications | 霍尼韦尔国际公司 | 2020-05-08 | — | — | CN | disclosed |
| US-10544329-B2 | Polysiloxane formulations and coatings for optoelectronic applications | HONEYWELL INTERNATIONAL INC. (US) | 2020-01-28 | — | — | US | disclosed |
| US-20190088464-A1 | THERMALLY REMOVABLE FILL MATERIALS FOR ANTI-STICTION APPLICATIONS | SOLSTICE ADVANCED MATERIALS US, INC. | 2019-03-21 | — | — | US | disclosed |
| EP-3430100-A1 | POLYSILOXANE FORMULATIONS AND COATINGS FOR OPTOELECTRONIC APPLICATIONS, METHODS OF PRODUCTION, AND USES THEREOF | HONEYWELL INTERNATIONAL INC. (US) | 2019-01-23 | — | — | EP | disclosed |
| US-20180022957-A1 | POLYSILOXANE FORMULATIONS AND COATINGS FOR OPTOELECTRONIC APPLICATIONS | HONEYWELL INTERNATIONAL INC. (US) | 2018-01-25 | — | — | US | disclosed |
| WO-2017160509-A1 | POLYSILOXANE FORMULATIONS AND COATINGS FOR OPTOELECTRONIC APPLICATIONS, METHODS OF PRODUCTION, AND USES THEREOF | HONEYWELL INTERNATIONAL INC. (US) | 2017-09-21 | — | — | WO | disclosed |
| US-20170260419-A1 | POLYSILOXANE FORMULATIONS AND COATINGS FOR OPTOELECTRONIC APPLICATIONS, METHODS OF PRODUCTION, AND USES THEREOF | HONEYWELL INTERNATIONAL INC. | 2017-09-14 | — | — | US | disclosed |
| EP-3194502-A1 | POLYSILOXANE FORMULATIONS AND COATINGS FOR OPTOELECTRONIC APPLICATIONS | Honeywell International Inc. (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016167892-A1 | POLYSILOXANE FORMULATIONS AND COATINGS FOR OPTOELECTRONIC APPLICATIONS | HONEYWELL INTERNATIONAL INC. (US) | 2016-10-20 | — | — | WO | disclosed |
| US-8901268-B2 | Compositions, layers and films for optoelectronic devices, methods of production and uses thereof | JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT | 2014-12-02 | — | — | US | disclosed |
| US-20110171447-A1 | COMPOSITIONS, LAYERS AND FILMS FOR OPTOELECTRONIC DEVICES, METHODS OF PRODUCTION AND USES THEREOF | JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT | 2011-07-14 | — | — | US | disclosed |
| WO-2008124711-A1 | COMPOSITIONS, LAYERS AND FILMS FOR OPTOELECTRONIC DEVICES, METHODS OF PRODUCTION AND USES THEREOF | HONEYWELL INTERNATIONAL INC. (US) | 2008-10-16 | — | — | WO | disclosed |
| US-20080157065-A1 | Compositions, layers and films for optoelectronic devices, methods of production and uses thereof | HONEYWELL INTERNATIONAL INC. | 2008-07-03 | — | — | US | disclosed |