Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | RAB9A | P51151 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.45 |
| ▸ | RELA | Q04206 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12324091 | 0.91 | NPC1 (0.46) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL12403514 | 0.91 | NPC1 (0.46) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL12402705 | 0.89 | NPC1 (0.46) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL12402653 | 0.89 | NPC1 (0.46) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL15127163 | 0.82 | NPC1 (0.40) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL12402654 | 0.81 | NPC1 (0.54) | NPC1RAB9AMEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL483931 | 0.80 | KDM4E (0.55) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL12323610 | 0.79 | NPC1 (0.51) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL13189300 | 0.79 | NPC1 (0.46) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL13189823 | 0.78 | KDM4E (0.40) | NPC1RAB9AMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411057-B1 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | LILLY CO ELI (US) | 2020-05-06 | — | — | EP | disclosed |