Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21975936 | 0.96 | MEN1 (0.42) | MEN1GAAKMT2ANPC1PLK1 | |
| SCHEMBL21976310 | 0.81 | HDAC6 (0.37) | MEN1GAAKMT2APLK1HDAC1 | |
| SCHEMBL23677092 | 0.78 | HDAC6 (0.42) | PLK1HDAC1HDAC6HDAC8POLB | |
| SCHEMBL21976470 | 0.76 | HDAC6 (0.55) | MEN1KMT2ANPC1HDAC1HDAC6 | |
| SCHEMBL21976251 | 0.76 | HDAC6 (0.52) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL21975922 | 0.75 | MEN1 (0.53) | MEN1GAAKMT2ANPC1HDAC6 | |
| SCHEMBL21976950 | 0.75 | HDAC1 (0.47) | GAAHDAC1HDAC6HDAC8KDM4E | |
| SCHEMBL21976968 | 0.75 | HDAC6 (0.50) | HDAC1HDAC6HDAC8ALOX5HDAC3 | |
| SCHEMBL13485782 | 0.74 | PLK1 (0.70) | NPC1PLK1HDAC1HDAC6HDAC8 | |
| SCHEMBL21976291 | 0.74 | KDM1A (0.43) | MEN1KMT2ANPC1HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294715-B1 | BENZIMIDAZOLE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | KANCERA AB (SE) | 2020-05-06 | — | — | EP | disclosed |