Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.31 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2198274 | 0.80 | CHRM2 (0.44) | MAPT | |
| SCHEMBL20471528 | 0.72 | AR (0.34) | POLBITGB1ITGA5MAPT | |
| SCHEMBL22978565 | 0.72 | AR (0.34) | POLBITGB1ITGA5MAPT | |
| SCHEMBL3607555 | 0.72 | AR (0.34) | POLBITGB1ITGA5MAPT | |
| SCHEMBL3336957 | 0.72 | AR (0.34) | POLBITGB1ITGA5MAPT | |
| SCHEMBL2198799 | 0.69 | — | — | |
| SCHEMBL3639157 | 0.68 | POLB (0.36) | POLB | |
| SCHEMBL2196433 | 0.64 | — | — | |
| SCHEMBL2715722 | 0.61 | ACE (0.56) | ITGB1ITGA5MEN1KMT2A | |
| SCHEMBL2805870 | 0.61 | ACE (0.56) | ITGB1ITGA5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152713-B1 | PYRAZOLOPYRROLIDINES AS INHIBITORS OF GAMMA SECRETASE | ELAN PHARM INC (US) | 2011-09-07 | — | — | EP | disclosed |
| US-7977368-B2 | Pyrazolopyrrolidines as inhibitors of gamma secretase | ELAN PHARMACEUTICALS, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| EP-2152713-A1 | PYRAZOLOPYRROLIDINES AS INHIBITORS OF GAMMA SECRETASE | Elan Pharmaceuticals Inc. (US) | 2010-02-17 | — | — | EP | disclosed |
| US-20090099235-A1 | Pyrazolopyrrolidines as Inhibitors of Gamma Secretase | ELAN PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
| WO-2008147800-A1 | PYRAZOLOPYRROLIDINES AS INHIBITORS OF GAMMA SECRETASE | ELAN PHARMACEUTICALS, INC. (US) | 2008-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099235-A1 | Pyrazolopyrrolidines as Inhibitors of Gamma Secretase | BACE1, BACE2, APP | POLB 2440/4885GAA 123/4885ITGB1 3129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.