Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21980312 | 1.00 | HDAC6 (0.53) | HDAC6PIK3CDPIK3CGHDAC8PIK3CA | |
| SCHEMBL22039312 | 0.91 | PIK3CD (0.43) | HDAC6PIK3CDPIK3CGHDAC8PIK3CA | |
| SCHEMBL22039345 | 0.90 | HDAC6 (0.48) | HDAC6PIK3CDPIK3CGHDAC8PIK3CA | |
| SCHEMBL22039351 | 0.89 | HDAC6 (0.43) | HDAC6PIK3CDPIK3CGHDAC8PIK3CA | |
| SCHEMBL21980286 | 0.88 | HDAC6 (0.42) | HDAC6PIK3CDPIK3CGHDAC8PIK3CA | |
| SCHEMBL21980283 | 0.88 | HDAC6 (0.42) | HDAC6PIK3CDPIK3CGHDAC8PIK3CA | |
| SCHEMBL22039666 | 0.88 | PIK3CD (0.51) | HDAC6PIK3CDPIK3CGHDAC8PIK3CA | |
| SCHEMBL21980294 | 0.86 | HDAC6 (0.55) | HDAC6PIK3CDPIK3CGHDAC8PIK3CA | |
| SCHEMBL21980292 | 0.86 | HDAC6 (0.55) | HDAC6PIK3CDPIK3CGHDAC8PIK3CA | |
| SCHEMBL21980291 | 0.85 | PIK3CG (0.47) | HDAC6PIK3CDPIK3CGHDAC8PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200165257-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE AND HISTONE DEACETYLASE FOR TREATMENT OF CANCER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200165257-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE AND HISTONE DEACETYLASE FOR TREATMENT OF CANCER | HDAC1, HDAC3, HDAC4 | HDAC6 10/4885PIK3CD 17/4885PIK3CG 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.