Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 20/20 | 0.58 |
| ▸ | IDH2 | P48735 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16391620 | 0.92 | IDH1 (0.66) | IDH1IDH2 | |
| SCHEMBL21976980 | 0.90 | IDH1 (0.61) | IDH1IDH2 | |
| SCHEMBL21980585 | 0.89 | IDH1 (0.62) | IDH1IDH2 | |
| SCHEMBL20018045 | 0.88 | IDH1 (0.66) | IDH1IDH2 | |
| SCHEMBL16392200 | 0.85 | IDH1 (0.57) | IDH1IDH2 | |
| SCHEMBL21982016 | 0.85 | IDH1 (0.48) | IDH1IDH2 | |
| SCHEMBL16391756 | 0.84 | IDH1 (0.79) | IDH1IDH2 | |
| SCHEMBL21977579 | 0.83 | IDH1 (0.73) | IDH1IDH2 | |
| SCHEMBL20018036 | 0.81 | IDH1 (0.75) | IDH1IDH2 | |
| SCHEMBL16392189 | 0.81 | IDH1 (0.64) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019480-B1 | 2,4- OR 4,6-DIAMINOPYRIMIDINE COMPOUNDS AS IDH2 MUTANTS INHIBITORS FOR THE TREATMENT OF CANCER | AGIOS PHARMACEUTICALS INC (US) | 2020-05-06 | — | — | EP | disclosed |