Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706160 | 0.85 | JAK3 (0.38) | JAK3USP2SMN1; SMN2GRIN2BGRIN2C | |
| SCHEMBL700241 | 0.82 | JAK3 (0.43) | JAK3USP2SMN1; SMN2GRIN2BGRIN2C | |
| SCHEMBL15286428 | 0.81 | JAK3 (0.46) | JAK3USP2SMN1; SMN2GRIN2BGRIN2C | |
| Hydrochloric Acid SCHEMBL19582520 | 0.81 | JAK3 (0.43) | JAK3USP2SMN1; SMN2GRIN2BGRIN2C | |
| Hydrochloric Acid SCHEMBL15288269 | 0.80 | JAK3 (0.45) | JAK3USP2SMN1; SMN2GRIN2BGRIN2C | |
| SCHEMBL14762409 | 0.80 | JAK3 (0.42) | JAK3USP2SMN1; SMN2GRIN2BGRIN2C | |
| SCHEMBL24491096 | 0.79 | JAK3 (0.37) | JAK3USP2SMN1; SMN2GRIN2BGRIN2C | |
| SCHEMBL26848595 | 0.79 | JAK3 (0.37) | JAK3USP2SMN1; SMN2GRIN2BGRIN2C | |
| Oxalic Acid SCHEMBL3984766 | 0.79 | JAK3 (0.41) | JAK3USP2SMN1; SMN2GRIN2BGRIN2C | |
| SCHEMBL17608804 | 0.79 | USP2 (0.46) | JAK3USP2SMN1; SMN2GRIN2BGRIN2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3647311-B1 | RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD AND USE THEREOF | BEIJING TIDE PHARMACEUTICAL CO LTD (CN) | 2023-11-01 | — | — | EP | disclosed |
| EP-3647311-A1 | RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD AND USE THEREOF | Beijing Tide Pharmaceutical Co., Ltd. (CN) | 2020-05-06 | — | — | EP | disclosed |