Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 20/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21985667 | 0.86 | PDE2A (0.68) | PDE2A | |
| SCHEMBL21985683 | 0.85 | PDE2A (0.66) | PDE2A | |
| SCHEMBL21985634 | 0.84 | PDE2A (0.60) | PDE2A | |
| SCHEMBL21985632 | 0.81 | PDE2A (0.70) | PDE2A | |
| SCHEMBL21985992 | 0.81 | PDE2A (0.69) | PDE2A | |
| SCHEMBL16867985 | 0.80 | PDE2A (1.00) | PDE2A | |
| SCHEMBL18388182 | 0.80 | PDE2A (1.00) | PDE2A | |
| SCHEMBL16867988 | 0.80 | PDE2A (1.00) | PDE2A | |
| SCHEMBL16868156 | 0.79 | PDE2A (1.00) | PDE2A | |
| SCHEMBL19571237 | 0.79 | PDE2A (1.00) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3087060-B1 | PYRIMIDONE CARBOXAMIDE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME (US) | 2020-05-13 | — | — | EP | disclosed |