Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 20/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.75 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.75 |
| ▸ | F2 | P00734 | 1/20 | 0.67 |
| ▸ | F11 | P03951 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19682291 | 0.93 | KLKB1 (0.66) | KLKB1CYP3A4CYP2C8CYP2C9F2 | |
| SCHEMBL29835938 | 0.87 | KLKB1 (1.00) | KLKB1CYP3A4CYP2C8CYP2C9F2 | |
| SCHEMBL17785395 | 0.87 | KLKB1 (1.00) | KLKB1CYP3A4CYP2C8CYP2C9F2 | |
| SCHEMBL17785423 | 0.86 | KLKB1 (1.00) | KLKB1CYP3A4CYP2C8CYP2C9F2 | |
| SCHEMBL17785373 | 0.86 | KLKB1 (1.00) | KLKB1CYP3A4CYP2C8CYP2C9F2 | |
| SCHEMBL21120927 | 0.85 | KLKB1 (0.89) | KLKB1CYP3A4CYP2C8CYP2C9F2 | |
| SCHEMBL17785346 | 0.84 | KLKB1 (0.88) | KLKB1CYP3A4CYP2C8CYP2C9F2 | |
| SCHEMBL21145566 | 0.84 | KLKB1 (0.88) | KLKB1CYP3A4CYP2C8CYP2C9F2 | |
| SCHEMBL21145618 | 0.84 | KLKB1 (1.00) | KLKB1CYP3A4CYP2C8CYP2C9F2 | |
| SCHEMBL17785418 | 0.83 | KLKB1 (0.85) | KLKB1CYP3A4CYP2C8CYP2C9F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3760622-A1 | PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2021-01-06 | — | — | EP | disclosed |
| EP-3464271-B1 | PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LTD (GB) | 2020-05-13 | — | — | EP | disclosed |