Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
| ▸ | CCNK | O75909 | 1/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.32 |
| ▸ | CFB | P00751 | 3/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2628879 | 0.80 | PRKCI (0.47) | AXLPRKCICCR1CCR5CCR8 | |
| SCHEMBL2628869 | 0.77 | AXL (0.53) | AXLPRKCICCR1CCR5CCR8 | |
| SCHEMBL27290679 | 0.74 | AXL (0.42) | AXLPRKCICCNKCDK12CFB | |
| SCHEMBL8735125 | 0.74 | PRKCI (0.42) | AXLPRKCICCR1CCR5CCR8 | |
| SCHEMBL16382707 | 0.73 | AXL (0.41) | AXLPRKCICCNKCDK12CFB | |
| SCHEMBL8737415 | 0.72 | AXL (0.47) | AXLPRKCICCR1CCR5CCR8 | |
| SCHEMBL3272742 | 0.72 | AXL (0.40) | AXLPRKCICFBPIK3C3 | |
| SCHEMBL16382691 | 0.70 | BTK (0.45) | AXLPRKCIPIK3C3JAK2JAK1 | |
| SCHEMBL15280126 | 0.69 | CYP1A2 (0.33) | AXLPRKCICCR8CFB | |
| SCHEMBL18479114 | 0.69 | AXL (0.53) | AXLPRKCICCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3172214-B1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE DERIVATIVES AS CDK INHIBITORS AND USES THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2020-05-13 | — | — | EP | disclosed |