Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | YTHDC1 | Q96MU7 | 4/20 | 0.37 |
| ▸ | YTHDF2 | Q9Y5A9 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 2/20 | 0.33 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.33 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14391670 | 0.85 | PI4KA (0.38) | PDPK1KMT2AMAPTPI4KAPI4K2B | |
| SCHEMBL5565969 | 0.83 | PDPK1 (0.45) | PDPK1YTHDC1YTHDF2KMT2ACSF1R | |
| SCHEMBL27099013 | 0.81 | PDPK1 (0.36) | PDPK1YTHDC1YTHDF2KMT2AMAPT | |
| SCHEMBL13701447 | 0.81 | PDPK1 (0.36) | PDPK1YTHDC1YTHDF2KMT2AMAPT | |
| SCHEMBL5565234 | 0.79 | PDPK1 (0.44) | PDPK1YTHDC1YTHDF2KMT2AMAPT | |
| SCHEMBL17622966 | 0.77 | PDPK1 (0.42) | PDPK1YTHDC1YTHDF2KMT2AMAPT | |
| SCHEMBL18312089 | 0.77 | LIMK1 (0.38) | PDPK1KMT2AMAPTPI4KAPI4K2B | |
| SCHEMBL18520578 | 0.77 | PDPK1 (0.30) | PDPK1 | |
| SCHEMBL18869129 | 0.76 | PDPK1 (0.41) | PDPK1YTHDC1YTHDF2KMT2AMAPT | |
| SCHEMBL27272883 | 0.76 | RET (0.32) | PI4KAPI4K2BPI4K2API4KBRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3401320-B1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS FOR USE IN TREATING HUMAN PAPILLOMA VIRUS, CERVICAL INTRAEPITHELIAL NEOPLASIA, ANAL INTRAEPITHELIAL NEOPLASIA, OR VULVAR INTRAEPITHELIAL NEOPLASIA | UNIV CALIFORNIA (US) | 2020-05-13 | — | — | EP | disclosed |