Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAP3K12 | Q12852 | 7/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17814858 | 0.80 | GBA1 (0.46) | GBA1HSD11B1CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL20115401 | 0.80 | GBA1 (0.46) | GBA1HSD11B1CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL24461156 | 0.77 | GBA1 (0.43) | GBA1HSD11B1CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL22098589 | 0.75 | GBA1 (0.42) | GBA1HSD11B1CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL26790067 | 0.75 | GBA1 (0.42) | GBA1HSD11B1CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL20115395 | 0.75 | GBA1 (0.42) | GBA1HSD11B1CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL18484868 | 0.75 | — | — | |
| SCHEMBL19938007 | 0.75 | GBA1 (0.48) | GBA1HSD11B1CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL23851396 | 0.74 | GBA1 (0.41) | GBA1HSD11B1CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL23851395 | 0.74 | GBA1 (0.41) | GBA1HSD11B1CYP2D6SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3172214-B1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE DERIVATIVES AS CDK INHIBITORS AND USES THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2020-05-13 | — | — | EP | disclosed |