Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 13/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21987039 | 0.85 | PTGDR2 (0.71) | PTGDR2AKR1B1TDP1 | |
| SCHEMBL21987043 | 0.82 | PTGDR2 (0.80) | PTGDR2TDP1POLBTSHRCTDSP1 | |
| SCHEMBL21987062 | 0.81 | PTGDR2 (0.59) | PTGDR2TDP1POLBTSHRCTDSP1 | |
| SCHEMBL5384687 | 0.78 | TDP1 (0.72) | PTGDR2MCL1TDP1TSHRPPARD | |
| SCHEMBL3044855 | 0.78 | PTGDR2 (0.79) | PTGDR2AKR1B1TDP1POLBTSHR | |
| SCHEMBL3203787 | 0.76 | TDP1 (0.70) | PTGDR2TDP1POLBTSHRCTDSP1 | |
| SCHEMBL21987035 | 0.76 | PTGDR2 (0.45) | PTGDR2AKR1B1 | |
| SCHEMBL21987061 | 0.76 | PTGDR2 (1.00) | PTGDR2AKR1B1TDP1POLBTSHR | |
| SCHEMBL8528987 | 0.75 | PTGDR2 (0.55) | PTGDR2MCL1TDP1TSHRL3MBTL1 | |
| SCHEMBL789387 | 0.74 | PTGDR2 (1.00) | PTGDR2AKR1B1TDP1POLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020109233-A2 | TRMT2A INHIBITORS FOR USE IN THE TREATMENT OF POLYGLUTAMINE DISEASES | FORSCHUNGSZENTRUM JÜLICH GMBH FACHBEREICH PATENTE (R-P) (DE) | 2020-06-04 | — | — | WO | disclosed |
| EP-3659593-A1 | TRMT2A INHIBITORS FOR USE IN THE TREATMENT OF POLYGLUTAMINE DISEASES | Forschungszentrum Jülich GmbH/ Abteilung RP-PT (DE) | 2020-06-03 | — | — | EP | disclosed |