Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLR1A | O95602 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2198792 | 1.00 | KMT2A (0.39) | KMT2APOLR1AJAK1GPR119KDM1A | |
| SCHEMBL2202091 | 0.86 | MALT1 (0.40) | KMT2APOLR1AJAK1GPR119KDM1A | |
| SCHEMBL2202093 | 0.86 | MALT1 (0.40) | KMT2APOLR1AJAK1GPR119KDM1A | |
| SCHEMBL2197614 | 0.84 | KMT2A (0.44) | KMT2APOLR1AJAK1GPR119KDM1A | |
| SCHEMBL12510462 | 0.81 | KMT2A (0.43) | KMT2APOLR1AJAK1GPR119KDM1A | |
| SCHEMBL2201573 | 0.81 | KMT2A (0.43) | KMT2APOLR1AJAK1GPR119 | |
| SCHEMBL2201158 | 0.78 | KMT2A (0.41) | KMT2APOLR1AJAK1GPR119KDM1A | |
| SCHEMBL2200002 | 0.78 | KMT2A (0.47) | KMT2APOLR1AJAK1GPR119KDM1A | |
| SCHEMBL2198108 | 0.78 | KMT2A (0.41) | KMT2APOLR1AJAK1GPR119KDM1A | |
| SCHEMBL2199901 | 0.77 | MALT1 (0.49) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977358-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-07-12 | — | — | US | disclosed |
| EP-2182953-A2 | NEW PYRAZOL DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009013211-A2 | NEW PYRAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-29 | — | — | WO | disclosed |