Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.59 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.59 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.59 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 2/20 | 0.56 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | FADS1 | O60427 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24771257 | 0.93 | NPC1 (0.65) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL20774335 | 0.84 | NPC1 (0.57) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL21990931 | 0.83 | NPC1 (0.72) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL19479144 | 0.82 | NPC1 (0.67) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL17784044 | 0.81 | NPC1 (0.65) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL19157142 | 0.81 | NPC1 (0.65) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL2679067 | 0.81 | NPC1 (0.73) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL94560 | 0.81 | NPC1 (0.73) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL17784123 | 0.80 | NPC1 (0.47) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL24771971 | 0.80 | NPC1 (0.51) | NPC1RAB9AKCNQ3KCNQ2KCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227262-B1 | SULFIDE ALKYL AND PYRIDYL REVERSE SULFONAMIDE COMPOUNDS FOR HBV TREATMENT | NOVIRA THERAPEUTICS INC (US) | 2020-05-13 | — | — | EP | disclosed |