Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.47 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.47 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17792108 | 0.86 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2KCNQ3KCNQ2 | |
| SCHEMBL17784009 | 0.85 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2KCNQ3KCNQ2 | |
| SCHEMBL19473198 | 0.85 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2KCNQ3KCNQ2 | |
| SCHEMBL17792166 | 0.85 | NPC1 (0.54) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL21991727 | 0.85 | NPC1 (0.54) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL17784013 | 0.84 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2KCNQ3KCNQ2 | |
| SCHEMBL19473180 | 0.84 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2KCNQ3KCNQ2 | |
| SCHEMBL17792089 | 0.83 | NPC1 (0.50) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL17792162 | 0.83 | NPC1 (0.52) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL17784053 | 0.83 | NPC1 (0.52) | NPC1RAB9AKCNQ3KCNQ2KCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227262-B1 | SULFIDE ALKYL AND PYRIDYL REVERSE SULFONAMIDE COMPOUNDS FOR HBV TREATMENT | NOVIRA THERAPEUTICS INC (US) | 2020-05-13 | — | — | EP | disclosed |