Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | TP53 | P04637 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.38 |
| ▸ | RARA | P10276 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17784144 | 1.00 | MAPT (0.46) | MAPTTP53LMNAMAOBHTR2B | |
| SCHEMBL17784102 | 0.99 | MAPT (0.45) | MAPTTP53LMNAMAOBHTR2B | |
| SCHEMBL17784026 | 0.91 | MAPT (0.41) | MAPTTP53LMNAMAOBHTR2B | |
| SCHEMBL17792158 | 0.90 | TP53 (0.41) | MAPTTP53LMNAMAOBHTR2B | |
| SCHEMBL21991026 | 0.90 | TP53 (0.41) | MAPTTP53LMNAMAOBHTR2B | |
| SCHEMBL19473169 | 0.90 | TP53 (0.41) | MAPTTP53LMNAMAOBHTR2B | |
| SCHEMBL17784154 | 0.90 | TP53 (0.41) | MAPTTP53LMNAMAOBHTR2B | |
| SCHEMBL17792082 | 0.90 | TP53 (0.41) | MAPTTP53LMNAMAOBHTR2B | |
| SCHEMBL17784042 | 0.90 | TP53 (0.41) | MAPTTP53LMNAMAOBHTR2B | |
| SCHEMBL17784092 | 0.90 | TP53 (0.41) | MAPTTP53LMNAHTR2BKCNQ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227262-B1 | SULFIDE ALKYL AND PYRIDYL REVERSE SULFONAMIDE COMPOUNDS FOR HBV TREATMENT | NOVIRA THERAPEUTICS INC (US) | 2020-05-13 | — | — | EP | disclosed |