Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.42 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.42 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17792185 | 0.84 | NPC1 (0.47) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL19473192 | 0.84 | NPC1 (0.46) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL17792183 | 0.76 | KCNQ3 (0.45) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL19473196 | 0.75 | KCNQ3 (0.44) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL19473180 | 0.75 | NPC1 (0.55) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL17784065 | 0.75 | NPC1 (0.50) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL17784155 | 0.74 | NPC1 (0.56) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL24771149 | 0.74 | GRM4 (0.46) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL17784095 | 0.74 | NPC1 (0.57) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL17792086 | 0.74 | NPC1 (0.54) | NPC1RAB9AKCNQ3KCNQ2KCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227262-B1 | SULFIDE ALKYL AND PYRIDYL REVERSE SULFONAMIDE COMPOUNDS FOR HBV TREATMENT | NOVIRA THERAPEUTICS INC (US) | 2020-05-13 | — | — | EP | disclosed |