Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.82 |
| ▸ | MEN1 | O00255 | 10/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.78 |
| ▸ | GAA | P10253 | 2/20 | 0.78 |
| ▸ | GFER | P55789 | 1/20 | 0.78 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.73 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.73 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.65 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | CDC7 | O00311 | 1/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2199726 | 1.00 | MCHR1 (0.82) | MCHR1MEN1KMT2AGAAGFER | |
| SCHEMBL822697 | 0.96 | MEN1 (0.84) | MCHR1MEN1KMT2AGAAGFER | |
| SCHEMBL822507 | 0.91 | MEN1 (0.76) | MCHR1MEN1KMT2AGAAGFER | |
| SCHEMBL4352294 | 0.89 | MEN1 (0.78) | MCHR1MEN1KMT2AGAAGFER | |
| SCHEMBL4352297 | 0.89 | MEN1 (0.78) | MCHR1MEN1KMT2AGAAGFER | |
| SCHEMBL4355372 | 0.89 | GRIN1 (0.78) | MCHR1MEN1KMT2AGAAGFER | |
| SCHEMBL4355367 | 0.89 | GRIN1 (0.78) | MCHR1MEN1KMT2AGAAGFER | |
| SCHEMBL4348152 | 0.88 | MEN1 (0.76) | MCHR1MEN1KMT2AGAAGFER | |
| SCHEMBL4348827 | 0.88 | MEN1 (0.76) | MCHR1MEN1KMT2AGAAGFER | |
| SCHEMBL4348150 | 0.88 | MEN1 (0.76) | MCHR1MEN1KMT2AGAAGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090197870-A1 | Pharmaceutical Compositions | EXELIXIS, INC. (US) | 2009-08-06 | — | — | US | claimed |
| EP-1805154-A2 | PHARMACEUTICAL COMPOSITIONS | Exelixis, Inc. (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006047269-A2 | PHARMACEUTICAL COMPOSITIONS | EXELIXIS, INC. (US) | 2006-05-04 | — | — | WO | claimed |
| US-7977489-B2 | Benzylthiazolone inhibitors of estrogen-related receptors (ERR) | EXELIXIS, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-20090197870-A1 | Pharmaceutical Compositions | EXELIXIS, INC. (US) | 2009-08-06 | — | — | US | disclosed |
| US-20090197870-A1 | Pharmaceutical Compositions | EXELIXIS, INC. (US) | 2009-08-06 | — | — | US | disclosed |
| EP-1805154-A2 | PHARMACEUTICAL COMPOSITIONS | Exelixis, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006047269-A2 | PHARMACEUTICAL COMPOSITIONS | EXELIXIS, INC. (US) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197870-A1 | Pharmaceutical Compositions | ESRRA, ESRRB, ESR2 | MCHR1 523/4885MEN1 3649/4885KMT2A 1309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.