⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL219983 | 1.00 | — | — | |
| SCHEMBL28351367 | 0.97 | NPC1 (0.32) | — | |
| SCHEMBL10149589 | 0.97 | NPC1 (0.32) | — | |
| SCHEMBL16020149 | 0.88 | — | — | |
| SCHEMBL18405341 | 0.79 | — | — | |
| SCHEMBL9111603 | 0.79 | — | — | |
| SCHEMBL9109064 | 0.79 | — | — | |
| SCHEMBL9111610 | 0.79 | — | — | |
| SCHEMBL9113419 | 0.77 | — | — | |
| SCHEMBL9113416 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180009793-A1 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP (US) | 2018-01-11 | — | — | US | disclosed |
| US-9663471-B2 | Pyrazole derivatives as modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORPORATION (US) | 2017-05-30 | — | — | US | disclosed |
| US-20140256780-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORPORATION (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140256727-A1 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP. (US) | 2014-09-11 | — | — | US | disclosed |
| US-8772326-B2 | Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity | Anigion Biomedica Corp. (US) | 2014-07-08 | — | — | US | disclosed |
| US-20140171419-A1 | ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLECULE MODULATORS HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP (US) | 2014-06-19 | — | — | US | disclosed |
| US-8580834-B2 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP. (US) | 2013-11-12 | — | — | US | disclosed |
| US-20130252288-A1 | ENANTIOSELECTIVE REDUCTION | DSM IP ASSETS B.V. (NL) | 2013-09-26 | — | — | US | disclosed |
| US-20130190376-A1 | METHODS OF USE OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP | 2013-07-25 | — | — | US | disclosed |
| US-20120190668-A1 | ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLEUCLE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-07-26 | — | — | US | disclosed |
| EP-2173696-A1 | PREPARATION OF A SATURATED ALDEHYDE | DSM IP Assets B.V. (NL) | 2010-04-14 | — | — | EP | disclosed |
| EP-2171077-A2 | ENANTIOSELECTIVE REDUCTION | DSM IP Assets B.V. (NL) | 2010-04-07 | — | — | EP | disclosed |
| US-20090197895-A1 | OXAZOLE-PYRROLE-PIPERAZINE ALPHA-HELIX MIMETIC | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-08-06 | — | — | US | disclosed |
| WO-2009007460-A2 | ENANTIOSELECTIVE REDUCTION | DSM IP ASSETS B.V. (NL) | 2009-01-15 | — | — | WO | disclosed |
| WO-2009007461-A1 | PREPARATION OF A SATURATED ALDEHYDE | DSM IP ASSETS B.V. (NL) | 2009-01-15 | — | — | WO | disclosed |
| WO-2009007462-A1 | ALPHA-SUBSTITUTED α,β-UNSATURATED E- OR Z-ALDEHYDES, USE THEREOF, AND PROCESSES FOR THEIR PREPARATION α,β | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO. KG (AT) | 2009-01-15 | — | — | WO | disclosed |
| US-20080015243-A1 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP. | 2008-01-17 | — | — | US | disclosed |
| US-7265112-B2 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP. (US) | 2007-09-04 | — | — | US | disclosed |
| US-7250437-B2 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP. (US) | 2007-07-31 | — | — | US | disclosed |
| US-7192976-B2 | 3-substituted pyrazoles; cell proliferation and angiogenesis promoters; antiapoptotosis and antifibrosis activity | ANGION BIOMEDICA CORPORATION (US) | 2007-03-20 | — | — | US | disclosed |