Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNKP | Q96T60 | 8/20 | 1.00 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22000245 | 1.00 | PNKP (1.00) | PNKPHCRTR1HCRTR2USP2HSD17B10 | |
| SCHEMBL22000411 | 1.00 | PNKP (1.00) | PNKPHCRTR1HCRTR2USP2HSD17B10 | |
| SCHEMBL22000409 | 0.81 | PNKP (0.68) | PNKPHCRTR1HCRTR2USP2HSD17B10 | |
| SCHEMBL22000262 | 0.75 | PNKP (0.60) | PNKPUSP2HSD17B10KMT2AKDM4E | |
| SCHEMBL22000254 | 0.73 | PNKP (1.00) | PNKPHCRTR1HCRTR2USP2HSD17B10 | |
| SCHEMBL22000400 | 0.69 | PNKP (1.00) | PNKP | |
| SCHEMBL22000401 | 0.69 | PNKP (1.00) | PNKP | |
| SCHEMBL22000425 | 0.66 | PNKP (0.71) | PNKPHCRTR1HCRTR2USP2HSD17B10 | |
| SCHEMBL11405630 | 0.61 | MEN1 (0.69) | HSD17B10MEN1KMT2AALDH1A1 | |
| SCHEMBL4369528 | 0.60 | GAA (0.54) | PNKPHCRTR1HCRTR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200148675-A1 | IMIDOPIPERIDINE COMPOUNDS AS INHIBITORS OF HUMAN POLYNUCLEOTIDE KINASE PHOSPHATASE | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200148675-A1 | IMIDOPIPERIDINE COMPOUNDS AS INHIBITORS OF HUMAN POLYNUCLEOTIDE KINASE PHOSPHATASE | PNKP, PPM1A, PPM1B | PNKP 1/4885HCRTR1 4839/4885HCRTR2 4807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.