Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 4/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.39 |
| ▸ | HRH1 | P35367 | 4/20 | 0.39 |
| ▸ | HTR2B | P41595 | 4/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.39 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24220939 | 0.86 | MERTK (0.48) | MERTKKDM1AMAOBCKS1BSKP1 | |
| SCHEMBL29361761 | 0.86 | MERTK (0.48) | MERTKKDM1AMAOBCKS1BSKP1 | |
| SCHEMBL6459459 | 0.81 | MERTK (0.46) | MERTKKDM1AMAOBCKS1BSKP1 | |
| SCHEMBL6459470 | 0.81 | MERTK (0.46) | MERTKKDM1AMAOBCKS1BSKP1 | |
| SCHEMBL6464159 | 0.79 | MCHR1 (0.64) | MERTKKDM1AMAOBCKS1BSKP1 | |
| SCHEMBL6464155 | 0.79 | MCHR1 (0.64) | MERTKKDM1AMAOBCKS1BSKP1 | |
| SCHEMBL22570115 | 0.78 | MERTK (0.45) | MERTKKDM1AMAOBCKS1BSKP1 | |
| SCHEMBL28483806 | 0.78 | MERTK (0.45) | MERTKKDM1AMAOBCKS1BSKP1 | |
| SCHEMBL25042174 | 0.78 | MERTK (0.45) | MERTKKDM1AMAOBCKS1BSKP1 | |
| SCHEMBL25495372 | 0.77 | CKS1B (0.42) | MERTKKDM1AMAOBCKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11021466-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2021-06-01 | — | — | US | disclosed |
| US-20200157079-A1 | IRE1 Small Molecule Inhibitors | QUENTIS THERAPEUTICS, INC. (US) | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157079-A1 | IRE1 Small Molecule Inhibitors | XBP1, ERN2, ERN1 | MERTK 2689/4885KDM1A 2007/4885MAOB 4686/4885 |
| US-11021466-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | MERTK 2689/4885KDM1A 2007/4885MAOB 4686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.