Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 9/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2199871 | 0.86 | TOP1 (0.51) | TOP1P2RX7POLB | |
| SCHEMBL2202775 | 0.83 | TOP1 (0.49) | TOP1P2RX7 | |
| SCHEMBL1974822 | 0.82 | TOP1 (0.48) | TOP1P2RX7POLB | |
| SCHEMBL12427312 | 0.81 | TOP1 (0.47) | TOP1P2RX7POLB | |
| SCHEMBL12427350 | 0.81 | TOP1 (0.48) | TOP1P2RX7 | |
| SCHEMBL2207572 | 0.81 | TOP1 (0.46) | TOP1SMN1; SMN2 | |
| SCHEMBL13744618 | 0.80 | TOP1 (0.45) | TOP1P2RX7POLB | |
| SCHEMBL4251735 | 0.80 | TOP1 (0.45) | TOP1P2RX7POLB | |
| SCHEMBL13744928 | 0.80 | TOP1 (0.45) | TOP1P2RX7POLB | |
| SCHEMBL1971493 | 0.80 | TOP1 (0.45) | TOP1P2RX7PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977349-B2 | Substituted quinolones III | AICURIS GMBH & CO. KG (DE) | 2011-07-12 | — | — | US | disclosed |