Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.82 |
| ▸ | CDK4 | P11802 | 19/20 | 0.82 |
| ▸ | CCND1 | P24385 | 19/20 | 0.82 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.69 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.68 |
| ▸ | CCND3 | P30281 | 1/20 | 0.68 |
| ▸ | CDK9 | P50750 | 1/20 | 0.68 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16074602 | 0.90 | CDK4 (1.00) | CDK2CDK4CCND1 | |
| SCHEMBL16074625 | 0.89 | CDK4 (1.00) | CDK2CDK4CCND1 | |
| SCHEMBL22005235 | 0.89 | CDK2 (0.81) | CDK2CDK4CCND1CCNE1CCNT1 | |
| SCHEMBL16074605 | 0.88 | CDK2 (1.00) | CDK2CDK4CCND1CCNE1CCNT1 | |
| SCHEMBL16074612 | 0.84 | CDK2 (1.00) | CDK2CDK4CCND1CCNE1 | |
| SCHEMBL19036384 | 0.84 | CDK2 (1.00) | CDK2CDK4CCND1CCNE1 | |
| SCHEMBL16074609 | 0.84 | CDK2 (1.00) | CDK2CDK4CCND1CCNE1CCNT1 | |
| SCHEMBL22551643 | 0.83 | CDK2 (1.00) | CDK2CDK4CCND1CCNE1CCNT1 | |
| SCHEMBL10082029 | 0.83 | CDK2 (1.00) | CDK2CDK4CCND1CCNE1CCNT1 | |
| SCHEMBL22005377 | 0.82 | CDK4 (0.85) | CDK2CDK4CCND1CCNE1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3653209-A1 | TRANSIENT PROTECTION OF NORMAL CELLS DURING CHEMOTHERAPY | G1 Therapeutics, Inc. (US) | 2020-05-20 | — | — | EP | disclosed |