Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 20/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27486147 | 0.84 | IDH1 (0.73) | IDH1 | |
| SCHEMBL17807045 | 0.84 | IDH1 (1.00) | IDH1 | |
| SCHEMBL19713523 | 0.82 | IDH1 (1.00) | IDH1 | |
| SCHEMBL19725577 | 0.82 | IDH1 (1.00) | IDH1 | |
| SCHEMBL19713522 | 0.82 | IDH1 (1.00) | IDH1 | |
| SCHEMBL17806802 | 0.80 | IDH1 (1.00) | IDH1 | |
| SCHEMBL17806760 | 0.80 | IDH1 (0.80) | IDH1 | |
| SCHEMBL22006165 | 0.80 | IDH1 (0.70) | IDH1 | |
| SCHEMBL17806729 | 0.79 | IDH1 (1.00) | IDH1 | |
| SCHEMBL19713551 | 0.78 | IDH1 (1.00) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3226690-B1 | NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES | MERCK SHARP & DOHME (US) | 2020-05-20 | — | — | EP | disclosed |