Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.53 |
| ▸ | AGXT | P21549 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24603048 | 0.93 | KCNH2 (0.51) | KCNH2AGXTCYP1A2CYP2A6TAAR1 | |
| SCHEMBL19543321 | 0.91 | AGXT (0.50) | KCNH2AGXTCYP1A2CYP2A6TAAR1 | |
| SCHEMBL7388809 | 0.89 | KCNH2 (0.53) | KCNH2AGXTCYP1A2CYP2A6TAAR1 | |
| SCHEMBL16151476 | 0.89 | KCNH2 (0.62) | KCNH2AGXTCYP1A2CYP2A6TAAR1 | |
| SCHEMBL28506052 | 0.86 | KCNH2 (0.57) | KCNH2AGXTHCAR2TDP1L3MBTL1 | |
| SCHEMBL19249035 | 0.85 | AGXT (0.45) | KCNH2AGXTCA1CA2CA9 | |
| SCHEMBL9008786 | 0.82 | KCNH2 (0.59) | KCNH2AGXTCYP1A2CYP2A6TAAR1 | |
| SCHEMBL12270447 | 0.82 | AGXT (0.58) | KCNH2AGXTCYP1A2CYP2A6TAAR1 | |
| SCHEMBL20325300 | 0.81 | KCNH2 (0.56) | KCNH2AGXTCYP1A2CYP2A6TAAR1 | |
| SCHEMBL21026178 | 0.81 | KCNH2 (0.50) | KCNH2AGXTCYP1A2CYP2A6TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200155689-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | ARVINAS OPERATIONS, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200155689-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | CRBN, CBL, MDM2 | KCNH2 4867/4885AGXT 3549/4885CYP1A2 4681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.