⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3054314 | 0.85 | KDM4E (0.42) | — | |
| SCHEMBL18602744 | 0.82 | — | — | |
| SCHEMBL431070 | 0.82 | KDM4E (0.52) | — | |
| SCHEMBL15534200 | 0.75 | KDM4E (0.46) | — | |
| SCHEMBL21217103 | 0.73 | — | — | |
| SCHEMBL18602503 | 0.70 | — | — | |
| SCHEMBL25042763 | 0.69 | KCNH2 (0.52) | — | |
| SCHEMBL1196335 | 0.69 | — | — | |
| SCHEMBL16359796 | 0.69 | — | — | |
| SCHEMBL1142602 | 0.69 | KCNH2 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5734056-A | Process for the preparation of certain 9-substituted camptothecins | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-31 | — | — | US | claimed |
| EP-2148882-B1 | PROCESS FOR MAKING TOPOTECAN | SCINOPHARM TAIWAN LDT (TW) | 2012-06-20 | — | — | EP | disclosed |
| US-7977483-B2 | Process for making topotecan | SCINOPHARM TAIWAN, LTD. (TW) | 2011-07-12 | — | — | US | disclosed |
| EP-2148882-A1 | PROCESS FOR MAKING TOPOTECAN | Scinopharm Taiwan, Ldt. (TW) | 2010-02-03 | — | — | EP | disclosed |
| US-20090221826-A1 | Process for making topotecan | SCINOPHARM TAIWAN, LTD. (TW) | 2009-09-03 | — | — | US | disclosed |
| WO-2008127606-A1 | PROCESS FOR MAKING TOPOTECAN | SCINOPHARM TAIWAN, LDT. (TW) | 2008-10-23 | — | — | WO | disclosed |
| EP-0547165-B1 | Process for the Preparation of Water-Soluble Camptothecin Analogues, as well as the compounds 10-Hydroxy-11-C(1-6)-alkoxycamptothecin | SMITHKLINE BEECHAM CORP (US) | 1999-11-10 | — | — | EP | disclosed |
| US-5734056-A | Process for the preparation of certain 9-substituted camptothecins | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-31 | — | — | US | disclosed |
| EP-0547165-A4 | — | — | 1994-03-30 | — | — | EP | disclosed |
| EP-0547165-A1 | WATER SOLUBLE CAMPTOTHECIN ANALOGUES, PROCESSES AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-06-23 | — | — | EP | disclosed |
| WO-1992005785-A1 | WATER SOLUBLE CAMPTOTHECIN ANALOGUES, PROCESSES AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-04-16 | — | — | WO | disclosed |