Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | MAPK7 | Q13164 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CCKAR | P32238 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2202132 | 1.00 | KMT2A (0.40) | KMT2ASCN9ASCN10ANOTUMHSD11B1 | |
| SCHEMBL2198057 | 1.00 | KMT2A (0.40) | KMT2ASCN9ASCN10ANOTUMHSD11B1 | |
| SCHEMBL2200049 | 1.00 | KMT2A (0.40) | KMT2ASCN9ASCN10ANOTUMHSD11B1 | |
| SCHEMBL2201212 | 0.88 | HRH3 (0.41) | KMT2ASCN9ASCN10ANOTUMHSD11B1 | |
| SCHEMBL13973649 | 0.88 | KMT2A (0.40) | KMT2ASCN9ASCN10ANOTUMHSD11B1 | |
| SCHEMBL2201691 | 0.88 | SCN9A (0.41) | KMT2ASCN9ASCN10ANOTUMHSD11B1 | |
| SCHEMBL12429708 | 0.87 | KMT2A (0.40) | KMT2ASCN9ASCN10ANOTUMHSD11B1 | |
| SCHEMBL2203329 | 0.87 | KMT2A (0.40) | KMT2ASCN9ASCN10ANOTUMHSD11B1 | |
| SCHEMBL12429781 | 0.87 | KMT2A (0.40) | KMT2ASCN9ASCN10ANOTUMHSD11B1 | |
| SCHEMBL2203789 | 0.87 | KMT2A (0.40) | KMT2ASCN9ASCN10ANOTUMHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977358-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-07-12 | — | — | US | disclosed |