Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBE2D3 | P61077 | 1/20 | 0.69 |
| ▸ | MAOB | P27338 | 9/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20642934 | 1.00 | UBE2D3 (0.69) | UBE2D3MAOBGRM5MAOAHTR6 | |
| SCHEMBL20642987 | 1.00 | UBE2D3 (0.69) | UBE2D3MAOBGRM5MAOAHTR6 | |
| SCHEMBL20642970 | 0.91 | UBE2D3 (0.75) | UBE2D3MAOBGRM5MAOAFFAR4 | |
| SCHEMBL22009464 | 0.91 | UBE2D3 (0.75) | UBE2D3MAOBGRM5MAOAFFAR4 | |
| SCHEMBL22009470 | 0.90 | UBE2D3 (0.72) | UBE2D3MAOBMAOA | |
| SCHEMBL20642979 | 0.90 | UBE2D3 (0.67) | UBE2D3MAOBGRM5MAOA | |
| SCHEMBL20642940 | 0.90 | UBE2D3 (0.67) | UBE2D3MAOBGRM5MAOAHTR6 | |
| SCHEMBL22010118 | 0.90 | UBE2D3 (0.67) | UBE2D3MAOBGRM5MAOAHTR6 | |
| SCHEMBL20643021 | 0.90 | UBE2D3 (0.67) | UBE2D3MAOBGRM5MAOAHTR6 | |
| SCHEMBL20642958 | 0.90 | UBE2D3 (0.71) | UBE2D3MAOBMAOAACHEGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11034663-B2 | Tetrahydronaphtho[1,2-b]furan-2(3H)-one derivatives and preparation and uses thereof | Shanghai Qingdong Biotechnology Co., Ltd (CN) | 2021-06-15 | — | — | US | disclosed |
| US-20200199089-A1 | TETRAHYDRONAPHTHO[1,2-B]FURAN-2(3H)-ONE DERIVATIVES AND PREPARATION AND USES THEREOF | Shanghai Qingdong Biotechnology Co., Ltd. (CN) | 2020-06-25 | — | — | US | disclosed |
| EP-3653614-A1 | TETRAHYDRONAPHTHO[1,2-B]FURAN-2(3H)-ONE DERIVATIVE AND PREPARATION AND USE THEREOF IN PHARMACEUTICALS | Shanghai Qingdong Biotechnology Co., Ltd (CN) | 2020-05-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200199089-A1 | TETRAHYDRONAPHTHO[1,2-B]FURAN-2(3H)-ONE DERIVATIVES AND PREPARATION AND USES THEREOF | NR0B1, FOXM1, CYP1A1 | UBE2D3 2113/4885MAOB 987/4885GRM5 1155/4885 |
| US-11034663-B2 | Tetrahydronaphtho[1,2-b]furan-2(3H)-one derivatives and preparation and uses thereof | NR0B1, FOXM1, CYP1A1 | UBE2D3 2113/4885MAOB 987/4885GRM5 1155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.