Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 14/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.36 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.36 |
| ▸ | LCP2 | Q13094 | 2/20 | 0.36 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30227755 | 1.00 | KDM4E (0.39) | KDM4EMAPTL3MBTL1MAP4K1CHRM4 | |
| SCHEMBL21990564 | 1.00 | KDM4E (0.39) | KDM4EMAPTL3MBTL1MAP4K1CHRM4 | |
| SCHEMBL24758536 | 0.85 | MAP4K1 (0.49) | KDM4EMAPTL3MBTL1MAP4K1RPS6KA2 | |
| SCHEMBL30227793 | 0.85 | MAP4K1 (0.49) | KDM4EMAPTL3MBTL1MAP4K1RPS6KA2 | |
| SCHEMBL29261208 | 0.83 | PIK3C3 (0.46) | — | |
| SCHEMBL23987780 | 0.83 | MAP4K1 (0.43) | MAP4K1LCP2 | |
| SCHEMBL29261209 | 0.83 | PIK3C3 (0.46) | — | |
| SCHEMBL23987757 | 0.82 | ADORA2A (0.40) | KDM4EMAPTL3MBTL1MAP4K1RPS6KA2 | |
| SCHEMBL24758723 | 0.82 | EGLN2 (0.39) | KDM4EMAPTL3MBTL1MAP4K1PRKD1 | |
| SCHEMBL23987759 | 0.82 | ADORA2A (0.40) | KDM4EMAPTL3MBTL1MAP4K1RPS6KA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118103369-A | Pyridolactam derivatives, preparation method and application thereof | 浙江海正药业股份有限公司 | 2024-05-28 | — | — | CN | disclosed |
| EP-3880676-B1 | 2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | PFIZER (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2023030478-A1 | PYRIDOLACTAM DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 浙江海正药业股份有限公司 | 2023-03-09 | — | — | WO | disclosed |
| WO-2021220185-A1 | AZALACTAM COMPOUNDS AS HPK1 INHIBITORS | PFIZER INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2020100027-A1 | 2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | PFIZER INC. (US) | 2020-05-22 | — | — | WO | disclosed |