Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5161662 | 0.87 | GAA (0.56) | GAAKMT2AMEN1SLC6A2SLC6A3 | |
| SCHEMBL18699858 | 0.84 | CYP1A2 (0.53) | GAAKMT2AMEN1SLC6A2SLC6A3 | |
| SCHEMBL6490488 | 0.78 | KMT2A (0.74) | GAAKMT2AMEN1SLC6A2SLC6A3 | |
| SCHEMBL18699685 | 0.76 | GAA (0.49) | GAAKMT2AMEN1SLC6A2SLC6A3 | |
| SCHEMBL5160350 | 0.75 | GAA (0.55) | GAAKMT2AMEN1SLC6A2SLC6A3 | |
| SCHEMBL20020504 | 0.75 | GAA (0.51) | GAAKMT2AMEN1SLC6A2SLC6A3 | |
| SCHEMBL30071250 | 0.74 | GAA (0.76) | GAAKMT2AMEN1SLC6A2SLC6A3 | |
| SCHEMBL626827 | 0.74 | GAA (0.76) | GAAKMT2AMEN1SLC6A2SLC6A3 | |
| SCHEMBL20020808 | 0.73 | KMT2A (0.49) | GAAKMT2AMEN1SLC6A2SLC6A3 | |
| SCHEMBL4709278 | 0.73 | KMT2A (0.58) | GAAKMT2AMEN1SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3708566-A1 | NOVEL HETEROCYCLIC COMPOUNDS AND THE USE THEREOF IN MEDICINE AND IN COSMETICS | Galderma Research & Development (FR) | 2020-09-16 | — | — | EP | disclosed |
| WO-2020099885-A1 | HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS | THE UNIVERSITY OF SHEFFIELD (GB) | 2020-05-22 | — | — | WO | disclosed |