SCHEMBL22015381

SCHEMBL22015381

Cc1cccn2c(C(C)(CC(C)C)NC=O)ncc12

nearest known ligand 0.55

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SSTR4 P31391 20/20 0.55
SSTR1 P30872 3/20 0.43
SSTR2 P30874 2/20 0.40
SSTR3 P32745 2/20 0.40
SSTR5 P35346 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22015379 0.81 SSTR4 (0.54) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL17755134 0.78 SSTR4 (0.48) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL22015337 0.75 SSTR4 (0.60) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL17763049 0.72 SSTR4 (1.00) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL24047692 0.71 SSTR4 (0.51) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL17763221 0.70 SSTR4 (0.69) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL24048372 0.70 SSTR4 (0.55) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL16255896 0.70 SSTR4 (0.48) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL31740699 0.67 SSTR4 (0.42) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL31740327 0.66 SSTR4 (0.51) SSTR4SSTR1SSTR2SSTR3SSTR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3218372-B1 MORPHOLINE AND 1,4-OXAZEPANE AMIDES AS SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS BOEHRINGER INGELHEIM INT (DE) 2020-05-20 EP disclosed