Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 0.55 |
| ▸ | GRM6 | O15303 | 2/20 | 0.55 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.55 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.55 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.55 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.55 |
| ▸ | GSR | P00390 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.55 |
| ▸ | GRM5 | P41594 | 1/20 | 0.55 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.55 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.55 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.55 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.55 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.55 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.55 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.55 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.55 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamic Acid SCHEMBL515160 | 1.00 | GRM8 (0.55) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL27218911 | 1.00 | GRM8 (0.55) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL16290410 | 1.00 | GRM8 (0.55) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL27572769 | 1.00 | GRM8 (0.55) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL194964 | 0.96 | GRM8 (0.50) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL27622200 | 0.96 | GRM8 (0.50) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL19856868 | 0.94 | GRM8 (0.49) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL29255769 | 0.94 | CYP1A2 (0.49) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL19856866 | 0.94 | GRM8 (0.49) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL8852502 | 0.94 | CYP1A2 (0.49) | GRM8GRM6GRM7GRM4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891771-A1 | Compositions comprising lysine and ascorbate compounds for the treatment and prevention of cardiovascular diseases | Health Now, Inc. (US) | 1999-01-20 | — | — | EP | claimed |
| US-4761471-A | INDUCE BONE FORMATION IN ANIMALS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1988-08-02 | — | — | US | claimed |
| US-20210060116-A1 | PEPTIDES AND METHODS FOR TREATMENT OF NEURODEGENERATIVE DISEASES | UNIV INDIANA RES & TECH CORP (US) | 2021-03-04 | — | — | US | disclosed |
| US-10864244-B2 | Peptides and methods for treatment of neurodegenerative diseases | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2020-12-15 | — | — | US | disclosed |
| CN-108658243-B | Method for quickly removing organic pollutants in coal gas wastewater | 天津科技大学 | 2020-07-03 | — | — | CN | disclosed |
| US-20190054137-A1 | PEPTIDES AND METHODS FOR TREATMENT OF NEURODEGENERATIVE DISEASES | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2019-02-21 | — | — | US | disclosed |
| CN-108658243-A | A kind of method of quick removal coal gas wastewater organic pollution | 天津科技大学 | 2018-10-16 | — | — | CN | disclosed |
| WO-2017147044-A1 | PEPTIDES AND METHODS FOR TREATMENT OF NEURODEGENERATIVE DISEASES | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2017-08-31 | — | — | WO | disclosed |
| US-7977550-B2 | Non-toxic endophytes, plants injected therewith and methods for injecting plants | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2011-07-12 | — | — | US | disclosed |
| US-20090255015-A1 | NON-TOXIC ENDOPHYTES, PLANTS INJECTED THEREWITH AND METHODS FOR INJECTING PLANTS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS | 2009-10-08 | — | — | US | disclosed |
| US-7553654-B2 | Non-toxic endophytes, plants injected therewith and methods for injecting plants | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2009-06-30 | — | — | US | disclosed |
| US-20020094996-A1 | Compositions and methods for lowering plasma lipoprotein(a) and risk factors of cardiovascular diseases | RATH MATTHIAS (NL) | 2002-07-18 | — | — | US | disclosed |
| WO-2002028379-A2 | COMPOSITIONS AND METHODS FOR LOWERING PLASMA LIPOPROTEIN(A) AND RISK FACTORS OF CARDIOVASCULAR DISEASES | RATH MATTHIAS (US) | 2002-04-11 | — | — | WO | disclosed |
| WO-2002013616-A2 | PLANTS INFECTED WITH NON-TOXIC ENDOPHYTES | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2002-02-21 | — | — | WO | disclosed |
| US-5976861-A | PROTEINS FOR THE ISOLATION OF ANTIBODIES. | PHARMACIA BIOTECH AKTIEBOLAG (SE) | 1999-11-02 | — | — | US | disclosed |
| EP-0891771-A1 | Compositions comprising lysine and ascorbate compounds for the treatment and prevention of cardiovascular diseases | Health Now, Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| US-5438120-A | Purified Bordetella pertussius antigen used in vaccine against whooping cough; side effect reduction | BURROUGHS WELLCOME CO. (US) | 1995-08-01 | — | — | US | disclosed |
| US-5141870-A | Transforming plants with mutant fragment confers herbicide resistance | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-08-25 | — | — | US | disclosed |
| US-5013659-A | Hybrid to resist sulfonylureas | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-05-07 | — | — | US | disclosed |
| US-5000953-A | Biologically active substance | KAKEN CHEMICAL CO., LTD. (JP) | 1991-03-19 | — | — | US | disclosed |