SCHEMBL22015642

SCHEMBL22015642

Cc1cccn2c(C3(C(C)C)CCC3)ncc12

nearest known ligand 0.48

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SSTR4 P31391 19/20 0.48
SSTR1 P30872 1/20 0.34
NR1I2 O75469 1/20 0.33
HSD11B1 P28845 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16255995 0.83 SSTR4 (0.50) SSTR4
SCHEMBL16255996 0.80 SSTR4 (0.48) SSTR4SSTR1NR1I2HSD11B1
SCHEMBL16256114 0.74 SSTR4 (0.53) SSTR4SSTR1
SCHEMBL22015338 0.74 SSTR4 (0.58) SSTR4SSTR1
SCHEMBL17755135 0.72 SSTR4 (0.49) SSTR4SSTR1
SCHEMBL22015681 0.70 SSTR4 (0.56) SSTR4SSTR1
SCHEMBL31740327 0.69 SSTR4 (0.51) SSTR4SSTR1
SCHEMBL16255958 0.68 SSTR4 (0.64) SSTR4SSTR1
SCHEMBL12670774 0.68 SSTR4 (0.40) SSTR4SSTR1
SCHEMBL16255906 0.67 SSTR4 (0.49) SSTR4SSTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3218372-B1 MORPHOLINE AND 1,4-OXAZEPANE AMIDES AS SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS BOEHRINGER INGELHEIM INT (DE) 2020-05-20 EP disclosed