SCHEMBL22015963

SCHEMBL22015963

CC(C)(NC=O)c1noc2c(Cl)cccc12

nearest known ligand 0.54

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SSTR4 P31391 18/20 0.54
CHRNA7 P36544 1/20 0.36
HTR3A P46098 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22015743 0.84 SSTR4 (0.53) SSTR4
SCHEMBL22015378 0.83 SSTR4 (0.54) SSTR4
SCHEMBL23886270 0.80 SSTR4 (0.65) SSTR4
SCHEMBL17755284 0.76 SSTR4 (0.48) SSTR4CHRNA7HTR3A
SCHEMBL17755311 0.76 SSTR4 (0.60) SSTR4
SCHEMBL31560766 0.75 SSTR4 (0.54) SSTR4
SCHEMBL31560828 0.74 SSTR4 (0.53) SSTR4
SCHEMBL22015383 0.71 SSTR4 (0.55) SSTR4
SCHEMBL16252728 0.70 SSTR4 (1.00) SSTR4
SCHEMBL19724494 0.70 SSTR4 (1.00) SSTR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3218372-B1 MORPHOLINE AND 1,4-OXAZEPANE AMIDES AS SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS BOEHRINGER INGELHEIM INT (DE) 2020-05-20 EP disclosed