SCHEMBL22015970

SCHEMBL22015970

COc1cccn2c(C(C)(C)NC=O)ncc12

nearest known ligand 0.56

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SSTR4 P31391 20/20 0.56
SSTR1 P30872 3/20 0.39
SSTR2 P30874 2/20 0.36
SSTR3 P32745 2/20 0.36
SSTR5 P35346 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22015379 0.83 SSTR4 (0.54) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL16255962 0.79 SSTR4 (0.64) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL16255897 0.78 SSTR4 (0.51) SSTR4SSTR1
Hydrochloric Acid SCHEMBL28654994 0.77 SSTR4 (0.50) SSTR4SSTR1
SCHEMBL28673718 0.74 SSTR4 (0.53) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL16255849 0.72 SSTR4 (1.00) SSTR4SSTR1
SCHEMBL19724906 0.72 SSTR4 (1.00) SSTR4SSTR1
SCHEMBL19724444 0.71 SSTR4 (0.72) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL24048643 0.71 SSTR4 (0.76) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL29013369 0.71 SSTR4 (0.76) SSTR4SSTR1SSTR2SSTR3SSTR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3218372-B1 MORPHOLINE AND 1,4-OXAZEPANE AMIDES AS SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS BOEHRINGER INGELHEIM INT (DE) 2020-05-20 EP disclosed