Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 6/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 6/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 6/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 4/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.32 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22016970 | 0.91 | ITGB1 (0.43) | ITGB1ITGA4ITGB7 | |
| SCHEMBL22016973 | 0.91 | ITGB1 (0.43) | ITGB1ITGA4ITGB7 | |
| SCHEMBL22016954 | 0.91 | ITGB1 (0.39) | ITGB1ITGA4ITGB7GRM4 | |
| SCHEMBL21957313 | 0.89 | ITGB1 (0.49) | ITGB1ITGA4ITGB7 | |
| SCHEMBL21957315 | 0.89 | ITGB1 (0.49) | ITGB1ITGA4ITGB7 | |
| SCHEMBL22016617 | 0.89 | ITGB1 (0.49) | ITGB1ITGA4ITGB7 | |
| SCHEMBL22017579 | 0.88 | ITGB1 (0.40) | ITGB1ITGA4ITGB7 | |
| SCHEMBL22016967 | 0.87 | ITGB1 (0.39) | ITGB1ITGA4ITGB7 | |
| SCHEMBL22017222 | 0.87 | ITGB1 (0.40) | ITGB1ITGA4ITGB7 | |
| SCHEMBL21956873 | 0.86 | ITGB1 (0.49) | ITGB1ITGA4ITGB7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | GILEAD SCIENCES, INC. | 2022-04-21 | — | — | US | disclosed |
| US-11116760-B2 | Quinoline derivatives | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | ITGB1 3359/4885ITGA4 3235/4885ITGB7 2700/4885 |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | ITGB1 3359/4885ITGA4 3235/4885ITGB7 2700/4885 |
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | ITGB7, ITGB1, ITGA2B | ITGB1 2/4885ITGA4 4/4885ITGB7 1/4885 |
| US-11116760-B2 | Quinoline derivatives | CFTR, NQO1, IRF3 | ITGB1 3359/4885ITGA4 3235/4885ITGB7 2700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.